Improvement of Glycemic Control in Subjects With Poorly Controlled Type 2 Diabetes: Comparison of two treatment algorithms using insulin glargine

• Published in: Diabetes care Vol. 28; no. 6; pp. 1282 - 1288
• Main Authors: Davies, Melanie, Storms, Fred, Shutler, Simon, Bianchi-Biscay, Monique, Gomis, Ramon
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.06.2005
• Subjects: Algorithms; analogs & derivatives; Biological and medical sciences; blood; blood glucose; Blood Glucose - drug effects; Blood Glucose - metabolism; Blood sugar; Body Mass Index; Care and treatment; Comparative analysis; Diabetes; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - drug therapy; Diabetes. Impaired glucose tolerance; Dosage and administration; drug effects; Drug therapy; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; fasting; Female; glycemic control; Humans; hypoglycemia; Hypoglycemic Agents; Hypoglycemic Agents - therapeutic use; Innovations; Insulin; Insulin - analogs & derivatives; Insulin - therapeutic use; Insulin Glargine; Insulin, Long-Acting; Male; Medical sciences; metabolism; Middle Aged; noninsulin-dependent diabetes mellitus; Patient outcomes; Patient Selection; prospective studies; Safety; therapeutic use; therapeutics; titration; Treatment Outcome; Type 2 diabetes; weight gain; United Kingdom; Human; Insulin glargine; Treatment; Algorithm; Comparative study; Glycemia

OBJECTIVE:--Large prospective studies have demonstrated that optimum glycemic control is not routinely achieved in clinical practice. Barriers to optimal insulin therapy include hypoglycemia, weight gain, and suboptimal initiation and dose titration. This study compared two treatment algorithms for...