Biomimetic Radical Chemistry and Applications

• Main Author: Chatgilialoglu, Chryssostomos
• Format: eBook
• Language: English
• Published: MDPI - Multidisciplinary Digital Publishing Institute 2020
• Subjects: 2-thiouracil; 2c-3e S?S-bonded intermediates; 5]-radical translocation; 6-dioxa-4-azaspiro[4.5]decane; 8-cyclopurines; 8-oxo-dG; albumin; anomeric spironucleosides; ATRPase; azides; azidoalkylation; beta cells; bio-mimicking catalyst; bioinspired chemical catalysis; Biology, life sciences; biomimetic radical reaction; carboazidation; catalase activity; cell micropolarity maps; cellular response; charge transfer; chemical nuclease; circular dichroism; confocal microscopy; copper; cross-link; diabetes; DNA; DNA damage; DNA hole transfer; DNA methylation; DNA oxidation; DNA replication stress; electron holes; electron transfer; EPR spectroscopy; Fenton reaction; fragmentation; free fatty acids; free radical oxidation; free radicals; gamma radiolysis; genomic and epigenomic instability; glycogen phosphorylase; gold nanoparticles; guanine quadruplexes; heme; histone modifications; hydrogen peroxide; hydroxynonenal; inhomogeneous reactions; intercalation; iron porphyrin; iron(IV)-oxo; iron-mediated ATRP; isomerization; Julia–Kocienski olefination; kinetic studies; laser flash photolysis; lipid bilayer membranes; lipidomics; liposomal somatostatin; Mathematics and Science; membrane fluidity maps; miRNAs; mitochondrial uncoupling protein; modified nucleosides; nucleobase derivatives; nucleosides; OH and ?N3 radicals; oligonucleotides; oxidation; oxidative damage; oxidative DNA damage; oxononenal; peroxidation; photo-ionization; photolysis; protein labeling; protein stability; pulse radiolysis; Q1-390; QH301-705.5; quantum dynamics; radical reaction; radicals; radiolysis; radiosensitizers; Raman spectroscopy; reaction mechanism; reactive aldehydes; replication fork stalling; retarded delivery; singlet oxygen; stationary radiolysis; sulfones; TD-DFT methods; therapeutic proteins; thiobases; thiyl radicals; time-resolved spectroscopy; trans lipid; type 2 diabetes

The enormous importance of free radical chemistry for a variety of biological events, including ageing and inflammation, has attracted a strong interest in understanding the related mechanistic steps at the molecular level. Modelling the free radical chemical reactivity of biological systems is an i...