Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs

• Published in: The FASEB journal Vol. 20; no. 11; pp. 1855 - 1864
• Main Authors: Hunt, Mary C, Rautanen, Anna, Westin, Maria A.K, Svensson, L. Thomas, Alexson, Stefan E.H
• Format: Journal Article
• Language: English
• Published: United States The Federation of American Societies for Experimental Biology 01.09.2006
• Subjects: Amino Acid Sequence; Animals; Base Sequence; Cloning, Molecular; DNA Primers; Evolution, Molecular; Humans; Mice; Molecular Sequence Data; Multigene Family; Open Reading Frames; Palmitoyl-CoA Hydrolase - genetics; Peroxisomes - enzymology; Reverse Transcriptase Polymerase Chain Reaction; Sequence Alignment; Sequence Homology, Amino Acid; Thiolester Hydrolases - genetics; Transcription, Genetic

The maintenance of cellular levels of free fatty acids and acyl-CoAs, the activated form of free fatty acids, is extremely important, as imbalances in lipid metabolism have serious consequences for human health. Acyl-coenzyme A (CoA) thioesterases (ACOTs) hydrolyze acyl-CoAs to the free fatty acid a...