ESR spectroscopy identifies inhibitory Cu2+ sites in a DNA-modifying enzyme to reveal determinants of catalytic specificity - Yang, Zhongyu; Kurpiewski, Michael R; Ji, Ming; Townsend, Jacque E; Mehta, Preeti; Jen-Jacobson, Linda; Saxena, Sunil (Proceedings of the National Academy of Sciences - PNAS, 2012)
Keywords: Biocatalysis; Biological Sciences; calorimetry; catalytic activity; Catalytic Domain; chemistry; Copper; Copper - metabolism; Dimerization; DNA; DNA - metabolism; DNA Modification Methylases; DNA Modification Methylases - chemistry; DNA Modification Methylases - metabolism; Electron Spin Resonance Spectroscopy; Electron Spin Resonance Spectroscopy - methods; histidine; Histidine - metabolism; ions; magnesium; metabolism; methods; molecular dynamics; Molecular Dynamics Simulation; nucleotide sequences; Physical Sciences; PNAS Plus; spectroscopy; titration