Associations between newly discovered polymorphisms in the Bos taurusgrowth hormone receptor gene and performance traits in Holstein-Friesian dairy cattle

• Published in: Animal genetics Vol. 42; no. 1; pp. 39 - 49
• Main Authors: Waters, S.M, McCabe, M.S, Howard, D.J, Giblin, L, Magee, D.A, MacHugh, D.E, Berry, D.P
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.02.2011; Wiley Subscription Services, Inc
• Subjects: Animals; association; Bos; calving; calving interval; Cattle; Dairy cattle; Dairy farms; DNA; Female; Genes; genetic merit; genetics; Genome-Wide Association Study; growth & development; growth hormone receptor; Growth hormones; Holstein; Holstein-Friesian; lactation; linkage disequilibrium; Male; Meat; Milk; milk yield; nucleotide sequences; Polymorphism, Single Nucleotide; Receptors, Somatotropin; Regression Analysis; single nucleotide polymorphism; sires; somatic cells; somatotropin

Variations in the growth hormone receptor (GHR) gene sequence are associated with performance traits in cattle. For example, the single nucleotide polymorphism (SNP) F279Y in transmembrane exon 8 has a strong association with milk yield. In this study, 32 previously unreported, putative novel SNPs (...