Structure of the EF-hand domain of polycystin-2 suggests a mechanism for Ca²⁺-dependent regulation of polycystin-2 channel activity - Petri, Edward T; Ćelić, Andjelka; Kennedy, Scott D; Ehrlich, Barbara E; Boggon, Titus J; Hodsdon, Michael E (Proceedings of the National Academy of Sciences - PNAS, 2010)
Keywords: Amino Acid Sequence; Autosomal dominant polycystic kidney; autosomal dominant polycystic kidney disease; Biological Sciences; Calcium; Calcium - metabolism; Chemical equilibrium; Conserved Sequence - genetics; Coordinate systems; EF hand motifs; EF Hand Motifs - genetics; Humans; hydrophobicity; Invertebrates; Models, Molecular; Molecular Sequence Data; nuclear magnetic resonance spectroscopy; Nuclear Magnetic Resonance, Biomolecular; Physiological regulation; Polycystic kidney diseases; Polycystic Kidney Diseases - genetics; Polycystic Kidney Diseases - metabolism; polycystins; Protein Conformation; Proteins; Sea urchins; Sequence Homology; TRPP Cation Channels - chemistry; TRPP Cation Channels - metabolism