blood-brain barrier significantly limits eflornithine entry into Trypanosoma brucei brucei infected mouse brain

• Published in: Journal of neurochemistry Vol. 107; no. 4; pp. 1136 - 1146
• Main Authors: Sanderson, Lisa, Dogruel, Murat, Rodgers, Jean, Bradley, Barbara, Thomas, Sarah Ann
• Format: Journal Article
• Language: English
• Published: Oxford Oxford, UK : Blackwell Publishing Ltd 01.11.2008; Blackwell; Blackwell Publishing Ltd
• Subjects: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette, Sub-Family B, Member 1 - deficiency; Biochemistry; Biological and medical sciences; blood-brain barrier; Blood-Brain Barrier - drug effects; Blood-Brain Barrier - parasitology; Blood-Brain Barrier - physiopathology; Brain; Brain - drug effects; Brain - parasitology; Carbon Isotopes; Carbon Isotopes - metabolism; choroid plexus; deficiency; Disease Models, Animal; drug effects; drug therapy; Eflornithine; Eflornithine - pharmacokinetics; Eflornithine - therapeutic use; General aspects; Human protozoal diseases; Infectious diseases; Medical sciences; metabolism; Mice; Mice, Inbred BALB C; Mice, Transgenic; Neurology; Parasites; Parasitic diseases; parasitology; pathogenicity; pathology; pharmacokinetics; Pharmacology; physiopathology; Protozoal diseases; Rodents; Sucrose; Sucrose - metabolism; therapeutic use; Time Factors; Tritium; Tritium - pharmacokinetics; Trypanocidal Agents; Trypanocidal Agents - pharmacokinetics; Trypanocidal Agents - therapeutic use; Trypanosoma brucei brucei; Trypanosoma brucei brucei - pathogenicity; Trypanosomiasis; Trypanosomiasis, African; Trypanosomiasis, African - drug therapy; Trypanosomiasis, African - pathology; Drug; Choroid plexus; Ependymal organ; Animal model; Protozoal disease; Rodentia; Central nervous system; Parasitosis; African sickness; Blood brain barrier; Suramin sodium; Blood; Encephalon; Infection; Resistance; Vertebrata; eflornithine; Mammalia; Mouse; Blood-brain barrier; Dysfunction; Animal; Trypanosomiasis

Drugs to treat African trypanosomiasis are toxic, expensive and subject to parasite resistance. New drugs are urgently being sought. Although the existing drug, eflornithine, is assumed to reach the brain in high concentrations, little is known about how it crosses the healthy and infected blood-bra...