Developmental Exposures of Male Rats to Soy Isoflavones Impact Leydig Cell Differentiation

• Published in: Biology of reproduction Vol. 83; no. 3; pp. 488 - 501
• Main Authors: Sherrill, Jessica D, Sparks, Morgan, Dennis, John, Mansour, Mahmoud, Kemppainen, Barbara W, Bartol, Frank F, Morrison, Edward E, Akingbemi, Benson T
• Format: Journal Article
• Language: English
• Published: Madison, WI Society for the Study of Reproduction, Inc 01.09.2010; Society for the Study of Reproduction; Oxford University Press
• Subjects: Analysis of Variance; Animals; Animals, Newborn; Biological and medical sciences; Blotting, Western; Cell Differentiation - drug effects; Cell Proliferation - drug effects; Estradiol - biosynthesis; Fundamental and applied biological sciences. Psychology; Glycine max; Immunohistochemistry; Isoflavones - pharmacology; Leydig Cells - drug effects; Leydig Cells - metabolism; Male; Mitogen-Activated Protein Kinases - metabolism; Rats; Rats, Long-Evans; Receptors, Androgen - metabolism; Receptors, LH - metabolism; Signal Transduction - drug effects; Testosterone - biosynthesis; Vertebrates: reproduction; Cell proliferation; Rat; Genistein; Male; Testicle; Isoflavone derivatives; Flavonoid; Leydig cell; Phytoestrogen; Polyphenol; Reproduction; Toxicology; Leydig cells; Development; Proanthocyanidin; Testicular hormone; testicular interstitial cells; Androgen; proliferation; Tyrosine kinase inhibitor; Rodentia; phytoestrogens; Antioxidant; Cell differentiation; Male genital system; soy isoflavones; developmental exposures; Interstitial cell; Testosterone; Vertebrata; Mammalia; Animal; Phenols; Sex steroid hormone

Testicular Leydig cells, which are the predominant source of the male sex steroid hormone testosterone, express estrogen receptors (ESRs) and are subject to regulation by estrogen. Following ingestion, the two major isoflavones in soybeans, genistin and daidzin, are hydrolyzed by gut microflora to f...