Validation of Continuous Glucose Monitoring in Children and Adolescents With Cystic Fibrosis: A prospective cohort study

• Published in: Diabetes care Vol. 32; no. 6; pp. 1020 - 1022
• Main Authors: O'Riordan, Stephen M.P, Hindmarsh, Peter, Hill, Nathan R, Matthews, David R, George, Sherly, Greally, Peter, Canny, Gerard, Slattery, Dubhfeasa, Murphy, Nuala, Roche, Edna, Costigan, Colm, Hoey, Hilary
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.06.2009
• Subjects: Adolescent; Analysis; Biological and medical sciences; Blood Glucose - metabolism; Child; Children; Clinical medicine; Cohort Studies; Cystic fibrosis; Cystic Fibrosis - blood; Dextrose; Diabetes; Diabetes Complications - blood; Diabetes. Impaired glucose tolerance; Diseases; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Errors of metabolism; Female; Glucose; Glucose Intolerance - blood; Glucose Tolerance Test; Glucose tolerance tests; Humans; Male; Medical sciences; Metabolic diseases; Methods; Miscellaneous; Miscellaneous hereditary metabolic disorders; Monitoring, Ambulatory - methods; Monitoring, Physiologic - methods; Mortality; Original Research; Patient monitoring equipment; Prospective Studies; Public health. Hygiene; Public health. Hygiene-occupational medicine; Reproducibility of Results; Research methodology; Sensitivity and Specificity; Studies; Teenagers; Young Adult; Human; Nutrition; Respiratory disease; Metabolic diseases; Cystic fibrosis; Genetic disease; Prospective; Test validation; Continuous Glucose Monitoring System; Cohort study; Adolescent; Digestive diseases; Child; Endocrinology; Public health; Pancreatic disease
• DOI: 10.2337/dc08-1925
• ISSN: 0149-5992

OBJECTIVE: To validate continuous glucose monitoring (CGM) in children and adolescents with cystic fibrosis. RESEARCH DESIGN AND METHODS: Paired oral glucose tolerance tests (OGTTs) and CGM monitoring was undertaken in 102 children and adolescents with cystic fibrosis (age 9.5-19.0 years) at baseline (CGM1) and after 12 months (CGM2). CGM validity was assessed by reliability, reproducibility, and repeatability. RESULTS: CGM was reliable with a Bland-Altman agreement between CGM and OGTT of 0.81 mmol/l (95% CI for bias ± 2.90 mmol/l) and good correlation between the two (r = 0.74-0.9; P < 0.01). CGM was reproducible with no significant differences in the coefficient of variation of the CGM assessment between visits and repeatable with a mean difference between CGM1 and CGM2 of 0.09 mmol/l (95% CI for difference ± 0.46 mmol/l) and a discriminant ratio of 13.0 and 15.1, respectively. CONCLUSIONS: In this cohort of children and adolescents with cystic fibrosis, CGM performed on two occasions over a 12-month period was reliable, reproducible, and repeatable.