Histone Demethylase JMJD2C Is Stage-Specifically Expressed in Preimplantation Mouse Embryos and Is Required for Embryonic Development

• Published in: Biology of reproduction Vol. 82; no. 1; pp. 105 - 111
• Main Authors: Wang, Jianle, Zhang, Miao, Zhang, Yu, Kou, Zhaohui, Han, Zhiming, Chen, Da-Yuan, Sun, Qing-Yuan, Gao, Shaorong
• Format: Journal Article
• Language: English
• Published: Madison, WI Society for the Study of Reproduction, Inc 2010; Society for the Study of Reproduction
• Subjects: Animals; Biological and medical sciences; Blastocyst - enzymology; Down-Regulation; Embryonic Development; Epigenesis, Genetic; Female; Fundamental and applied biological sciences. Psychology; Homeodomain Proteins - metabolism; Jumonji Domain-Containing Histone Demethylases; Kruppel-Like Transcription Factors - metabolism; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Nanog Homeobox Protein; Octamer Transcription Factor-3 - metabolism; Oxidoreductases, N-Demethylating - metabolism; Proto-Oncogene Proteins c-myc - metabolism; SOXB1 Transcription Factors - metabolism; Vertebrates: reproduction; Embryonic development; Embryo; RNAi; developmental biology; Rodentia; Blastocyst; JMJD2C; Early stage; histone demethylase; Vertebrata; Reproduction; early development; Mammalia; Mouse; Animal; Histone

Epigenetic modifications play a pivotal role in embryonic development by dynamically regulating DNA methylation and chromatin modifications. Although recent studies have shown that core histone methylation is reversible, very few studies have investigated the functions of the newly discovered histon...