Prion biology relevant to bovine spongiform encephalopathy

• Published in: Journal of animal science Vol. 83; no. 6; pp. 1455 - 1476
• Main Authors: Novakofski, J, Brewer, M. S, Mateus-Pinilla, N, Killefer, J, McCusker, R. H
• Format: Journal Article
• Language: English
• Published: Savoy, IL Am Soc Animal Sci 01.06.2005; American Society of Animal Science
• Subjects: amino acid sequences; Animal productions; animal proteins; Animals; Animals, Domestic; Biological and medical sciences; bovine spongiform encephalopathy; Cattle; chronic wasting disease; Decontamination; Deer; disease surveillance; disease transmission; Encephalopathy, Bovine Spongiform - diagnosis; Encephalopathy, Bovine Spongiform - genetics; Encephalopathy, Bovine Spongiform - transmission; Environment; feeds; food security; Fundamental and applied biological sciences. Psychology; genetic variation; Glycosylation; Goats; Humans; ingestion; literature reviews; meat and bone meal; molecular sequence data; pathogenesis; Prion Diseases - prevention & control; Prion Diseases - transmission; Prion Diseases - veterinary; prions; Prions - blood; Prions - pathogenicity; Prions - physiology; Prions - urine; protein conformation; proteinases; PrPSc proteins; Ruminantia; Scrapie - transmission; Sheep; Terrestrial animal productions; Vertebrates; Wasting Disease, Chronic - physiopathology; Wasting Disease, Chronic - transmission; Infection; Chronic Wasting Disease; Prion disease; Vertebrata; Mammalia; Bovine; Disease; Prion; Artiodactyla; Spongiform encephalopathy; Bovine Spongiform Encephalopathy; Ungulata

Bovine spongiform encephalopathy (BSE) and chronic wasting disease (CWD) of deer and elk are a threat to agriculture and natural resources, as well as a human health concern. Both diseases are transmissible spongiform encephalopathies (TSE), or prion diseases, caused by autocatalytic conversion of e...