Reduced blockade by extracellular Mg²⁺ is permissive to NMDA receptor activation in cerebellar granule neurons that model a migratory phenotype

• Published in: Journal of neurochemistry Vol. 114; no. 1; pp. 191 - 202
• Main Authors: Gerber, Adam M, Beaman-Hall, Carol M, Mathur, Anjili, Vallano, Mary Lou
• Format: Journal Article
• Language: English
• Published: Oxford, UK Oxford, UK : Blackwell Publishing Ltd 01.07.2010; Blackwell Publishing Ltd; Wiley-Blackwell
• Subjects: AMPA receptors; Biological and medical sciences; Brain; CaMK; Central nervous system; Central neurotransmission. Neuromudulation. Pathways and receptors; cerebellum; CREB; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; explant; Fundamental and applied biological sciences. Psychology; Genotype & phenotype; Medical sciences; Neurology; Neurons; Vertebrates: nervous system and sense organs; CaMK; Granule neuron; Central nervous system; Electrophysiology; Glutamate receptor; Activation; Extracellular; Survival; cerebellum; Encephalon; explant; Depolarization; Phenotype; CREB; Voltage; Development; Models; AMPA receptors; NMDA receptor; Biological receptor

J. Neurochem. (2010) 114, 191-202. NMDA receptors (NMDAR) contribute to neuronal development throughout the CNS. However, their mode(s) of activation preceding synaptic maturation is unclear, as they are not co-localized with alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate receptors (AMPARs) wh...