Isotsaokoin, an antifungal agent from Amomum tsao-ko
Bioassay-guided purification of a methanol extract from Amomum tsao-ko led to the isolation of the bicyclic nonane isotsaokoin (1) as the major active principle, an isomer of the previously reported tsaokoin (2). The stereochemical relationship of 1 and 2 was investigated by NOE experiments and Mosh...
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| Published in | Journal of natural products (Washington, D.C.) Vol. 67; no. 5; pp. 889 - 891 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
WASHINGTON
American Chemical Society
01.05.2004
Amer Chemical Soc American Society of Pharmacognosy |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Bioassay-guided purification of a methanol extract from Amomum tsao-ko led to the isolation of the bicyclic nonane isotsaokoin (1) as the major active principle, an isomer of the previously reported tsaokoin (2). The stereochemical relationship of 1 and 2 was investigated by NOE experiments and Mosher ester derivatization. Compound 1 showed antifungal activity against Trycophyton mentagrophytes. |
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| AbstractList | Bioassay-guided purification of a methanol extract from Amomum tsao-ko led to the isolation of the bicyclic nonane isotsaokoin (1) as the major active principle, an isomer of the previously reported tsaokoin (2). The stereochemical relationship of 1 and 2 was investigated by NOE experiments and Mosher ester derivatization. Compound 1 showed antifungal activity against Trycophyton mentagrophytes. |
| Author | Lee, J.Y Cho, S.C Moon, S.S |
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| DOI | 10.1021/np030464l |
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| Keywords | Monocotyledones Fruit Pharmacognosy Trichophyton mentagrophytes Enaldehyde In vitro Biological activity Medicinal plant Fungi Antifungal agent Folk medicine Angiospermae Plant origin Bicyclic compound Isolation Spermatophyta Fungi Imperfecti Secondary alcohol Thallophyta Structural analysis Zingiberaceae |
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| References | Dong, H (WOS:000079392800029) 1999; 50 Song, QS (WOS:000167589200013) 2001; 12 BAUER, AW (WOS:A19667525000040) 1966; 45 KAMCHONWONGPAISAN, S (WOS:A1995QM63200018) 1995; 36 Heilmann, J (WOS:000170281600019) 2001; 57 Martin, TS (WOS:000087758300016) 2000; 77 OHTANI, I (WOS:A1991FN00500006) 1991; 113 |
| References_xml | – volume: 36 start-page: 1821 year: 1995 ident: WOS:A1995QM63200018 article-title: AN ANTIMALARIAL PEROXIDE FROM AMOMUM KRERVANH PIERRE publication-title: TETRAHEDRON LETTERS contributor: fullname: KAMCHONWONGPAISAN, S – volume: 12 start-page: 227 year: 2001 ident: WOS:000167589200013 article-title: Tsaokoin, a new bicyclic nonane from Amomum tsao-ko publication-title: CHINESE CHEMICAL LETTERS contributor: fullname: Song, QS – volume: 113 start-page: 4092 year: 1991 ident: WOS:A1991FN00500006 article-title: HIGH-FIELD FT NMR APPLICATION OF MOSHER METHOD - THE ABSOLUTE-CONFIGURATIONS OF MARINE TERPENOIDS publication-title: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY contributor: fullname: OHTANI, I – volume: 45 start-page: 493 year: 1966 ident: WOS:A19667525000040 article-title: ANTIBIOTIC SUSCEPTIBILITY TESTING BY A STANDARDIZED SINGLE DISK METHOD publication-title: AMERICAN JOURNAL OF CLINICAL PATHOLOGY contributor: fullname: BAUER, AW – volume: 77 start-page: 667 year: 2000 ident: WOS:000087758300016 article-title: Constituents of Amomum tsao-ko and their radical scavenging and antioxidant activities publication-title: JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY contributor: fullname: Martin, TS – volume: 57 start-page: 1281 year: 2001 ident: WOS:000170281600019 article-title: Minor cytotoxic and antibacterial compounds from the rhizomes of Amomum aculeatum publication-title: PHYTOCHEMISTRY contributor: fullname: Heilmann, J – volume: 50 start-page: 899 year: 1999 ident: WOS:000079392800029 article-title: Eicosenones and methylated flavonols from Amomum koenigii publication-title: PHYTOCHEMISTRY contributor: fullname: Dong, H |
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| SubjectTerms | Amomum - chemistry Antifungal Agents - chemistry Antifungal Agents - isolation & purification Antifungal Agents - pharmacology Biological and medical sciences Borohydrides Bridged Bicyclo Compounds - chemistry Bridged Bicyclo Compounds - isolation & purification Bridged Bicyclo Compounds - pharmacology Chemistry, Medicinal General pharmacology Korea Life Sciences & Biomedicine Medical sciences Molecular Structure Nuclear Magnetic Resonance, Biomolecular Oxidation-Reduction Pharmacognosy. Homeopathy. Health food Pharmacology & Pharmacy Pharmacology. Drug treatments Plant Sciences Plants, Medicinal - chemistry Science & Technology Stereoisomerism Trichophyton - drug effects |
| Title | Isotsaokoin, an antifungal agent from Amomum tsao-ko |
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