Chemoprevention of indirect and direct chemical carcinogenesis by carotenoids as oxygen radical quenchers

• Published in: Annals of the New York Academy of Sciences Vol. 534; p. 584
• Main Authors: Santamaria, L. (University of Pavia, Pavia, Italy), Bianchi, A, Arnaboldi, A, Ravetto, C, Bianchi, L, Pizzala, R, Andreoni, L, Santagati, G, Bermond, P
• Format: Journal Article
• Language: English
• Published: United States 1988
• Subjects: Animals; Benzo(a)pyrene; beta Carotene; Canthaxanthin; Carcinogens; CARCINOMA; CARCINOME; CAROTENOIDE; CAROTENOIDES; CAROTENOIDS; Carotenoids - analogs & derivatives; Carotenoids - therapeutic use; COMPLEMENTATION; DIET; DIETA; ENRIQUECIMIENTO DE LOS ALIMENTOS; Female; FOOD ENRICHMENT; Free Radicals; Methoxsalen; Methylnitronitrosoguanidine; MICE; Mutagenicity Tests; Neoplasms, Experimental - chemically induced; Neoplasms, Experimental - prevention & control; PREVENCION; PREVENTION; PUVA Therapy; RATON; REGIME ALIMENTAIRE; RETINOL; Skin Neoplasms - chemically induced; Skin Neoplasms - prevention & control; SOURIS; VITAMINAS; VITAMINE; VITAMINS

Beta-carotene (BC) and canthaxanthine (CX), two carotenoids with and without pro-vitamin A activity, respectively, were found to help to prevent benzo[a]pyrene (BP)-induced skin carcinogenesis in the dark and BP photocarcinogenesis (UV 300-400 nm) when given as an oral supplement to female Swiss alb...