Against the Rules: Human Keratin K80: TWO FUNCTIONAL ALTERNATIVE SPLICE VARIANTS, K80 AND K80.1, WITH SPECIAL CELLULAR LOCALIZATION IN A WIDE RANGE OF EPITHELIA

• Published in: The Journal of biological chemistry Vol. 285; no. 47; pp. 36909 - 36921
• Main Authors: Langbein, Lutz, Eckhart, Leopold, Rogers, Michael A, Praetzel-Wunder, Silke, Schweizer, Juergen
• Format: Journal Article
• Language: English
• Published: United States American Society for Biochemistry and Molecular Biology 19.11.2010
• Subjects: Alternative Splicing; Animals; Blotting, Western; Cattle; Cell Biology; Cell Differentiation; Cells, Cultured; Epithelium - metabolism; Guinea Pigs; Hair - cytology; Hair - metabolism; Humans; In Situ Hybridization; Keratinocytes - cytology; Keratinocytes - metabolism; Keratins, Type II - genetics; Keratins, Type II - immunology; Keratins, Type II - metabolism; Mice; Microscopy, Immunoelectron; Peptide Fragments - immunology; RNA, Messenger - genetics; Skin - cytology; Skin - metabolism

Of the 54 human keratins, five members have, at present, only been characterized at the gene level. In this study we have investigated the expression patterns of keratin K80, whose gene is located at the centromeric end of the type II keratin gene domain. K80 possesses a number of highly unusual pro...