evaluation of the influence of medetomidine hydrochloride and atipamezole hydrochloride on the arrhythmogenic dose of epinephrine in dogs during halothane anesthesia

• Published in: Canadian journal of veterinary research Vol. 60; no. 1; pp. 1 - 6
• Main Authors: Pettifer, G.R, Dyson, D.H, McDonnell, W.N
• Format: Journal Article
• Language: English
• Published: Canada 1996
• Subjects: Adrenergic alpha-Agonists - pharmacology; Adrenergic alpha-Antagonists - pharmacology; alpha-adrenergic receptors; Anesthesia, Inhalation - veterinary; Animals; antagonists; arrhythmia; Arrhythmias, Cardiac - chemically induced; Arrhythmias, Cardiac - physiopathology; Arrhythmias, Cardiac - veterinary; blood pressure; Cardiovascular Physiological Phenomena; Cardiovascular System - drug effects; Dog Diseases - chemically induced; Dog Diseases - physiopathology; Dogs; Dose-Response Relationship, Drug; Drug Interactions; epinephrine; Epinephrine - adverse effects; Epinephrine - pharmacology; Female; Halothane; heart rate; Heart Rate - drug effects; Heart Rate - physiology; Imidazoles - pharmacology; Male; Medetomidine; Time Factors

Alterations in the arrhythmogenic dose of epinephrine (ADE) were determined following administration of medetomidine hydrochloride (750 micrograms/M2) and a saline placebo, or medetomidine hydrochloride (750 micrograms/M2), followed by specific medetomidine reversal agent, atipamezole hydrochloride...