Thermodynamic mechanism for inhibition of lactose permease by the phosphotransferase protein IIAᴳˡᶜ - Hariharan, Parameswaran; Balasubramaniam, Dhandayuthapani; Peterkofsky, Alan; Kaback, H. Ronald; Guan, Lan (Proceedings of the National Academy of Sciences - PNAS, 2015)
Keywords: bacteria; binding capacity; Biological Sciences; Calorimetry; Crystallography, X-Ray; Entropy; Escherichia coli - enzymology; Galactosides - metabolism; glucose; Glucose - metabolism; Hot Temperature; Kinetics; lactose; melibiose; Membrane Transport Proteins - metabolism; Models, Molecular; Mutant Proteins - metabolism; Phosphoenolpyruvate Sugar Phosphotransferase System - metabolism; Protein Binding; stoichiometry; titration; protein–protein interactions; ITC; protein conformation; sugar/cation symport; PTS