YopJ targets TRAF proteins to inhibit TLR-mediated NF-κB, MAPK and IRF3 signal transduction

• Published in: Cellular microbiology Vol. 9; no. 11; pp. 2700 - 2715
• Main Authors: Sweet, Charles R, Conlon, Joseph, Golenbock, Douglas T, Goguen, Jon, Silverman, Neal
• Format: Journal Article
• Language: English
• Published: Oxford, UK Oxford, UK : Blackwell Publishing Ltd 01.11.2007; Blackwell Publishing Ltd
• Subjects: Yersinia pestis
• ISSN: 1462-5814; 1462-5822
• DOI: 10.1111/j.1462-5822.2007.00990.x

The Yersinia pestis virulence factor YopJ is a potent inhibitor of the NF-κB and MAPK signalling pathways, however, its molecular mechanism and relevance to pathogenesis are the subject of much debate. In this report, we characterize the effects of this type III effector protein on bone fide signall...