Trypanosoma brucei gBP21: an arginine-rich mitochondrial protein that binds to guide RNA with high affinity

• Published in: The Journal of biological chemistry Vol. 272; no. 6; pp. 3749 - 3757
• Main Authors: Koller, J. (LMU Munchen, Martinsried, Germany.), Muller, U.F, Schmid, B, Missel, A, Kruft, V, Stuart, K, Goringer, H.U
• Format: Journal Article
• Language: English
• Published: United States 07.02.1997
• Subjects: Amino Acid Sequence; AMINO ACID SEQUENCES; Animals; ARGININA; ARGININE; Arginine - analysis; ARN; ARN MENSAJERO; ARN MESSAGER; Base Sequence; BINDING; BINDING PROTEINS; CHEMICAL COMPOSITION; Circular Dichroism; Cloning, Molecular; COMPOSICION QUIMICA; COMPOSITION CHIMIQUE; Electrophoresis, Polyacrylamide Gel; EXPRESION GENICA; EXPRESSION DES GENES; GBP21 GENE; GENBANK/U61382; GENE; GENE EXPRESSION; GENES; GUIDE RNA BINDING PROTEIN; MESSENGER RNA; MITOCHONDRIA; MITOCHONDRIE; MITOCONDRIA; MOLECULAR SEQUENCE DATA; NUCLEOTIDE SEQUENCE; Open Reading Frames; PEPTIDE; PEPTIDES; PEPTIDOS; POLYPEPTIDES; Protein Conformation; PROTEINAS AGLUTINANTES; PROTEINE DE LIAISON; Protozoan Proteins; Recombinant Proteins - chemistry; RNA; RNA, Guide - metabolism; RNA-Binding Proteins - chemistry; RNA-Binding Proteins - metabolism; SECUENCIA NUCLEOTIDICA; SEQUENCE NUCLEOTIDIQUE; STRUCTURAL GENES; TRYPANOSOMA BRUCEI; Trypanosoma brucei brucei - chemistry

RNA editing in Trypanosoma brucei is a mitochondrial RNA processing reaction that results in the insertion and deletion of uridylate residues into otherwise untranslatable mRNAs. The process is directed by guide RNAs which function to specify the edited sequence. RNA editing in vitro requires mitoch...