No Protective Effect of Calcitriol on β-Cell Function in Recent-Onset Type 1 Diabetes: The IMDIAB XIII trial
OBJECTIVE: We investigated whether supplementation of the active form of vitamin D (calcitriol) in recent-onset type 1 diabetes can protect β-cell function evaluated by C-peptide and improve glycemic control assessed by A1C and insulin requirement. RESEARCH DESIGN AND METHODS: Thirty-four subjects (...
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| Published in | Diabetes care Vol. 33; no. 9; pp. 1962 - 1963 |
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| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
American Diabetes Association
01.09.2010
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| Subjects | |
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| Abstract | OBJECTIVE: We investigated whether supplementation of the active form of vitamin D (calcitriol) in recent-onset type 1 diabetes can protect β-cell function evaluated by C-peptide and improve glycemic control assessed by A1C and insulin requirement. RESEARCH DESIGN AND METHODS: Thirty-four subjects (aged 11-35 years, median 18 years) with recent-onset type 1 diabetes and high basal C-peptide >0.25 nmol/l were randomized in a double-blind trial to 0.25 μg/day calcitriol or placebo and followed-up for 2 years. RESULTS: At 6, 12, and 24 months follow-up, A1C and insulin requirement in the calcitriol group did not differ from the placebo group. C-peptide dropped significantly (P < 0.001) but similarly in both groups, with no significant differences at each time point. CONCLUSIONS: At the doses used, calcitriol is ineffective in protecting β-cell function in subjects (including children) with recent-onset type 1 diabetes and high C-peptide at diagnosis. |
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| AbstractList | We investigated whether supplementation of the active form of vitamin D (calcitriol) in recent-onset type 1 diabetes can protect beta-cell function evaluated by C-peptide and improve glycemic control assessed by A1C and insulin requirement.OBJECTIVEWe investigated whether supplementation of the active form of vitamin D (calcitriol) in recent-onset type 1 diabetes can protect beta-cell function evaluated by C-peptide and improve glycemic control assessed by A1C and insulin requirement.Thirty-four subjects (aged 11-35 years, median 18 years) with recent-onset type 1 diabetes and high basal C-peptide >0.25 nmol/l were randomized in a double-blind trial to 0.25 microg/day calcitriol or placebo and followed-up for 2 years.RESEARCH DESIGN AND METHODSThirty-four subjects (aged 11-35 years, median 18 years) with recent-onset type 1 diabetes and high basal C-peptide >0.25 nmol/l were randomized in a double-blind trial to 0.25 microg/day calcitriol or placebo and followed-up for 2 years.At 6, 12, and 24 months follow-up, A1C and insulin requirement in the calcitriol group did not differ from the placebo group. C-peptide dropped significantly (P < 0.001) but similarly in both groups, with no significant differences at each time point.RESULTSAt 6, 12, and 24 months follow-up, A1C and insulin requirement in the calcitriol group did not differ from the placebo group. C-peptide dropped significantly (P < 0.001) but similarly in both groups, with no significant differences at each time point.At the doses used, calcitriol is ineffective in protecting beta-cell function in subjects (including children) with recent-onset type 1 diabetes and high C-peptide at diagnosis.CONCLUSIONSAt the doses used, calcitriol is ineffective in protecting beta-cell function in subjects (including children) with recent-onset type 1 diabetes and high C-peptide at diagnosis. OBJECTIVE: We investigated whether supplementation of the active form of vitamin D (calcitriol) in recent-onset type 1 diabetes can protect β-cell function evaluated by C-peptide and improve glycemic control assessed by A1C and insulin requirement. RESEARCH DESIGN AND METHODS: Thirty-four subjects (aged 11-35 years, median 18 years) with recent-onset type 1 diabetes and high basal C-peptide >0.25 nmol/l were randomized in a double-blind trial to 0.25 μg/day calcitriol or placebo and followed-up for 2 years. RESULTS: At 6, 12, and 24 months follow-up, A1C and insulin requirement in the calcitriol group did not differ from the placebo group. C-peptide dropped significantly (P < 0.001) but similarly in both groups, with no significant differences at each time point. CONCLUSIONS: At the doses used, calcitriol is ineffective in protecting β-cell function in subjects (including children) with recent-onset type 1 diabetes and high C-peptide at diagnosis. We investigated whether supplementation of the active form of vitamin D (calcitriol) in recent-onset type 1 diabetes can protect beta-cell function evaluated by C-peptide and improve glycemic control assessed by A1C and insulin requirement. Thirty-four subjects (aged 11-35 years, median 18 years) with recent-onset type 1 diabetes and high basal C-peptide >0.25 nmol/l were randomized in a double-blind trial to 0.25 microg/day calcitriol or placebo and followed-up for 2 years. At 6, 12, and 24 months follow-up, A1C and insulin requirement in the calcitriol group did not differ from the placebo group. C-peptide dropped significantly (P < 0.001) but similarly in both groups, with no significant differences at each time point. At the doses used, calcitriol is ineffective in protecting beta-cell function in subjects (including children) with recent-onset type 1 diabetes and high C-peptide at diagnosis. |
| Author | Cappa, Marco Pitocco, Dario Maggi, Daria Pozzilli, Paolo Cavallo, Maria Gisella Di Stasio, Enrico Bizzarri, Carla Suraci, Concetta Napoli, Nicola Manfrini, Silvia Ghirlanda, Giovanni |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/20805274$$D View this record in MEDLINE/PubMed |
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| Copyright | 2010 by the American Diabetes Association. 2010 |
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| References | 16911633 - Diabet Med. 2006 Aug;23(8):920-3 10027578 - Diabetologia. 1999 Jan;42(1):51-4 11705562 - Lancet. 2001 Nov 3;358(9292):1500-3 18339654 - Arch Dis Child. 2008 Jun;93(6):512-7 19267337 - Diabetes Metab Res Rev. 2009 May;25(4):325-8 15971062 - Diabetologia. 2005 Jul;48(7):1247-57 20357369 - Diabetes Care. 2010 Jul;33(7):1443-8 |
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| Snippet | OBJECTIVE: We investigated whether supplementation of the active form of vitamin D (calcitriol) in recent-onset type 1 diabetes can protect β-cell function... We investigated whether supplementation of the active form of vitamin D (calcitriol) in recent-onset type 1 diabetes can protect beta-cell function evaluated... |
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| SubjectTerms | Adolescent Adult c-peptide C-Peptide - metabolism calcitriol Calcitriol - pharmacology Calcitriol - therapeutic use Child children Diabetes Mellitus, Type 1 - drug therapy Diabetes Mellitus, Type 1 - metabolism Female Glycated Hemoglobin A - metabolism glycemic control Humans Hypoglycemic Agents - pharmacology Hypoglycemic Agents - therapeutic use Insulin - therapeutic use insulin-dependent diabetes mellitus Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - metabolism Male Original Research protective effect Young Adult |
| Title | No Protective Effect of Calcitriol on β-Cell Function in Recent-Onset Type 1 Diabetes: The IMDIAB XIII trial |
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