Two haplotypes of the P2X₇ receptor containing the Ala-348 to Thr polymorphism exhibit a gain-of-function effect and enhanced interleukin-1β secretion

• Published in: The FASEB journal Vol. 24; no. 8; pp. 2916 - 2927
• Main Authors: Stokes, Leanne, Fuller, Stephen J, Sluyter, Ronald, Skarratt, Kristen K, Gu, Ben J, Wiley, James S
• Format: Journal Article
• Language: English
• Published: The Federation of American Societies for Experimental Biology 01.08.2010

The P2X₇ receptor is an ATP-gated cation channel expressed in immune cells and plays a role in proinflammatory cytokine release from monocytes and macrophages. This study investigated the coinheritance of 12 functionally relevant single nucleotide polymorphisms (SNPs) in the human P2X₇ gene (P2RX7),...