Studies on the causation of adverse reactions in microfilaraemic host following diethylcarbamazine therapy (Dipetalonema viteae in Mastomys natalensis)

• Published in: Tropical medicine and parasitology Vol. 36; no. 1; pp. 21 - 24
• Main Authors: Singh, D.P, Rathore, S, Misra, S, Chatterjee, R.K, Ghatak, S, Sen, A.B
• Format: Journal Article
• Language: English
• Published: Germany 01.03.1985
• Subjects: Acanthocheilonema viteae; adverse effects; amines; anaphylaxis; Animals; Biogenic Amines - analysis; diethylcarbamazine; Diethylcarbamazine - adverse effects; Diethylcarbamazine - therapeutic use; Dipetalonema Infections - drug therapy; Filariasis - drug therapy; Histamine - toxicity; Muridae; rodents; Serotonin - toxicity

The mechanism of the adverse reaction in microfilaraemic subjects following diethylcarbamazine (DEC) therapy has remained an enigma. To study the mechanisms involved Mastomys natalensis infected with Dipetalonema viteae have been used. Animals showing up to 50 mf/5 cmm of blood did not show any perc...