Modification of aflatoxin B1 biotransformation in vitro and DNA binding in vivo by dietary broccoli in rats

• Published in: Journal of toxicology and environmental health Vol. 25; no. 3; p. 269
• Main Authors: Ramsdell, H.S, Eaton, D.L
• Format: Journal Article
• Language: English
• Published: United States 1988
• Subjects: ADN; Aflatoxin B1; AFLATOXINAS; AFLATOXINE; AFLATOXINS; Aflatoxins - metabolism; Aflatoxins - pharmacokinetics; Animals; BROCCOLI; BROCOLI; CARCINOGENOS; CARCINOGENS; CHOU BROCOLI; Cytochrome P-450 Enzyme System - metabolism; DIET; DIETA; DNA; DNA - metabolism; Glutathione - metabolism; Glutathione Transferase; Liver - metabolism; Male; Random Allocation; RAT; RATA; RATS; Rats, Inbred Strains; REGIME ALIMENTAIRE; SUBSTANCE CANCERIGENE; Vegetables

Cruciferous vegetables have been shown to have anticarcinogenic effects in animals but biochemical mechanisms have not been completely elucidated. The effects of dietary broccoli on in vivo DNA binding of the hepatocarcinogen aflatoxin B1 (AFB) and in vitro formation of the putative carcinogenic int...