Feeding of partially hydrogenated fish oils to rats in comparison with partially hydrogenated soybean oil and refined rapeseed oil. A combined chronic oral toxicity and carcinogenicity study with in utero phase

• Published in: Acta medica Scandinavica, supplementum Vol. 726; no. 726; pp. 1 - 89
• Main Authors: Duthie, I.F, Barlow, S.M, Ashby, R, Tesh, J.M, Whitney, J.C, Saunders, A, Chapman, E, Norum, K.R, Svaar, H, Opstvedt, J
• Format: Journal Article
• Language: English
• Published: Stockholm (Sweden) Almqvist and Wiksell 1988
• Subjects: ACEITE DE COLZA; ACEITE DE SOJA; ACEITES DE PESCADO; ACIDE ERUCIQUE; ACIDE GRAS; ACIDO ERUCICO; ACIDOS GRASOS; ANIMAL DE LABORATOIRE; ANIMALES DE LABORATORIO; Animals; Canola Oil; CARCINOGENOS; CARCINOGENS; cetoleic acid; Diet; ERUCIC ACID; Erucic Acids - analysis; FATTY ACIDS; Fatty Acids, Monounsaturated; Female; Fetus - drug effects; FISH OILS; Fish Oils - pharmacology; Fish Oils - toxicity; HUILE DE COLZA; HUILE DE POISSON; HUILE DE SOJA; INGESTION TOXICITY; LABORATORY ANIMALS; LESION; LESIONES; LESIONS; Longevity - drug effects; Male; Plant Oils - pharmacology; Pregnancy; RAPESEED OIL; RAT; RATA; RATS; Rats, Inbred Strains; SOYBEAN OIL; Soybean Oil - pharmacology; Soybean Oil - toxicity; SUBSTANCE CANCERIGENE; TOXICIDAD POR INGESTION; TOXICITE PAR INGESTION

Partially hydrogenated fish oils (PHFO) have been widely used in human food products for many years, particularly in Europe, North and South America and in South Africa. Animal studies, mainly with rapeseed oil, suggested that erucic acid might be responsible for morphological changes in the myocard...