P-Glycoprotein Inhibitory Activity of Indonesian Medicinal Plants in Human Breast Cancer Cells

• Published in: Natural product sciences Vol. 10; no. 6
• Main Authors: Kim, H.R. (Ewha Womans University, Seoul, Republic of Korea), Chung, S.Y. (Ewha Womans University, Seoul, Republic of Korea), Jeong, Y.H. (Ewha Womans University, Seoul, Republic of Korea), Go, E.J. (Ewha Womans University, Seoul, Republic of Korea), Han, A.R. (Ewha Womans University, Seoul, Republic of Korea), Kim, N.H. (Ewha Womans University, Seoul, Republic of Korea), Sung, M.K. (Ewha Womans University, Seoul, Republic of Korea), Song, G.A (Ewha Womans University, Seoul, Republic of Korea), Jang, J.O. (Ewha Womans University, Seoul, Republic of Korea), Nam, J.W. (Ewha Womans University, Seoul, Republic of Korea), Lee, H.J. (Ewha Womans University, Seoul, Republic of Korea), Seo, E.K. (Ewha Womans University, Seoul, Republic of Korea), E-mail: Yuny@ewha.ac.kr
• Format: Journal Article
• Language: English
• Published: 01.12.2004
• Subjects: CELLS; CELLULE; CELULAS; daunomycin; Indonesian plants; MCF-7/ADR cell; P-glycoprotem; PLANTAS; PLANTE; PLANTS
• ISSN: 1226-3907

In order to examine their effects on the P-glycoprotein (P-gp) activity in human breast cancer cells, MCF-7/ADR, one hundred Indonesian plant extracts were screened. Among them, the five chloroform extracts of Calotropis gigantea, Curcuma aeruginosa, Merremia, Sindora sumatrana, and Zingiber cassumunar, showed the most potent P-gp inhibitory activity. When each of these extracts was treated together with the anticancer agent, daunomycin, they increased the cytotoxic activity of daunomycin up to IC∧50 values of less than 6.62 μM, which is a value with a positive control, verapamil. Also, other 15 plant extracts exhibited significant P-gp inhibitory activity with IC∧50 values between 6.62 and 13.20 μM.