Polycystic Ovarian Syndrome: Evidence that Flutamide Restores Sensitivity of the Gonadotropin-Releasing Hormone Pulse Generator to Inhibition by Estradiol and Progesterone1

• Published in: The journal of clinical endocrinology and metabolism Vol. 85; no. 11; pp. 4047 - 4052
• Main Authors: Eagleson, Christine A, Gingrich, Melissa B, Pastor, Carmen L, Arora, Tania K, Burt, Christine M, Evans, William S, Marshall, John C
• Format: Journal Article
• Language: English
• Published: Endocrine Society 01.11.2000

Polycystic ovarian syndrome (PCOS) is a complex disorder with multiple abnormalities, including hyperandrogenism, ovulatory dysfunction, and altered gonadotropin secretion. The majority of patients have elevated LH levels in plasma and a persistent rapid frequency of LH (GnRH) pulse secretion, the m...