Spatial transcriptomics reveals profound subclonal heterogeneity and T-cell dysfunction in extramedullary myeloma

• Published in: Blood
• Main Authors: John, Mara, Helal, Moutaz, Düll, Johannes, Mattavelli, Greta, Stanojkovska, Emilia, Afrin, Nazia, Leipold, Alexander, Steinhardt, Maximilian J., Zhou, Xiang, Zihala, David, Sithara Anilkumar, Anjana, Mersi, Julia, Waldschmidt, Johannes M., Riedhammer, Christine, Kadel, Sophie, Truger, Marietta, Werner, Rudolf, Haferlach, Claudia, Einsele, Hermann, Kretzschmar, Kai, Jelínek, Tomáš, Rosenwald, Andreas, Kortüm, K. Martin, Riedel, Angela, Rasche, Leo
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 20.08.2024

•EMD mimics the architectural complexity of solid tumors, marked by diverse microenvironments, multiclonality, and TNFRSF17 and GPRC5D levels.•EMD shows infiltration of active T cells spatially confined to niches segregated from MM cells, potentially affecting the therapeutic response. [Display omit...