Combine two different dengue vaccines could efficiently target dengue-naive subjects. Comment to Macias A, Ruiz-Palacios G, Ramos-Castaneda J. Combine dengue vaccines to optimize effectiveness. Vaccine. 2020 Jun 26;38(31):4801– 4804

• Published in: Vaccine Vol. 39; no. 5; p. 779
• Main Author: Guy, Bruno
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Limited 29.01.2021
• Subjects: Allergy and Immunology; Antibodies; Antigens; Cellular structure; Dengue fever; Immune response (humoral); Immunization; Priming; Serotypes; Vaccines; Vector-borne diseases

[...]while TAK-003 vaccine induces high protection against DENV2 and to a lesser extent against DENV1 in both dengue-seropositive and -seronegative individuals, responses and protection are dominated by DENV2 and an inconclusive relative risk > 1 has been observed for DENV3 in seronegative vaccin...