Effect of Cellular Environment on the Selective Activation of the Vitamin D Receptor by 1α,25-Dihydroxyvitamin D3 and Its Analog 1α-Fluoro-16-Ene-20-Epi-23-Ene-26,27-Bishomo-25-Hydroxyvitamin D3 (Ro-26-9228)

• Published in: Molecular endocrinology (Baltimore, Md.) Vol. 18; no. 4; pp. 874 - 887
• Main Authors: Ismail, Ayesha, Nguyen, Cuong V, Ahene, Ago, Fleet, James C, Uskokovic, Milan R, Peleg, Sara
• Format: Journal Article
• Language: English
• Published: Endocrine Society 01.04.2004; Oxford University Press

The vitamin D analog, 1α-fluoro-16-ene-20-epi-23-ene-26,27-bishomo-25-hydroxyvitamin D3 (Ro-26-9228) is tissue selective, with a gene regulation preference for bone over duodenum in vivo. In the human osteoblast-like cells, hFOB, the vitamin D receptor (VDR)-mediated transcriptional potencies of Ro-...