Progressive Reduction in Cortical Thickness as Psychosis Develops: A Multisite Longitudinal Neuroimaging Study of Youth at Elevated Clinical Risk

• Published in: Biological psychiatry (1969) Vol. 77; no. 2; pp. 147 - 157
• Main Authors: Cannon, Tyrone D., Chung, Yoonho, He, George, Sun, Daqiang, Jacobson, Aron, van Erp, Theo G.M., McEwen, Sarah, Addington, Jean, Bearden, Carrie E., Cadenhead, Kristin, Cornblatt, Barbara, Mathalon, Daniel H., McGlashan, Thomas, Perkins, Diana, Jeffries, Clark, Seidman, Larry J., Tsuang, Ming, Walker, Elaine, Woods, Scott W., Heinssen, Robert
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.01.2015
• Subjects: Adolescent; Antipsychotic Agents - therapeutic use; Cerebral Cortex - drug effects; Cerebral Cortex - pathology; Cytokines - blood; Disease Progression; Female; Follow-Up Studies; Humans; Inflammation; Longitudinal Studies; Magnetic Resonance Imaging; Male; MRI; Organ Size; Prefrontal cortex; Prodromal; Prodromal Symptoms; Psychiatric/Mental Health; Psychosis; Psychotic Disorders - blood; Psychotic Disorders - drug therapy; Psychotic Disorders - pathology; Reproducibility of Results; Risk; Schizophrenia; Young Adult; Psychosis; Schizophrenia; Inflammation; Prefrontal cortex; MRI; Prodromal

Individuals at clinical high risk (CHR) who progress to fully psychotic symptoms have been observed to show a steeper rate of cortical gray matter reduction compared with individuals without symptomatic progression and with healthy control subjects. Whether such changes reflect processes associated...