Efficacy and safety of sirolimus in the treatment of vascular anomalies: A systematic review

• Published in: Journal of vascular surgery Vol. 71; no. 1; pp. 318 - 327
• Main Authors: Freixo, Cristiana, Ferreira, Vítor, Martins, Joana, Almeida, Rui, Caldeira, Daniel, Rosa, Mário, Costa, João, Ferreira, Joaquim
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2020
• Subjects: Sirolimus; Surgery; Vascular anomalies; Vascular malformations; Vascular tumors; Vascular malformations; Vascular tumors; Vascular anomalies; Sirolimus

The management of vascular anomalies is complex and requires a multidisciplinary team with a combination of medical, surgical, and intervention treatments. Medical treatment is limited and has conflicting results. Off-label use of mammalian target of rapamycin inhibitors shows promising results. The...