GluN3A excitatory glycine receptors control adult cortical and amygdalar circuits

• Published in: Neuron (Cambridge, Mass.) Vol. 110; no. 15; pp. 2438 - 2454.e8
• Main Authors: Bossi, Simon, Dhanasobhon, Dhanasak, Ellis-Davies, Graham C.R., Frontera, Jimena, de Brito Van Velze, Marcel, Lourenço, Joana, Murillo, Alvaro, Luján, Rafael, Casado, Mariano, Perez-Otaño, Isabel, Bacci, Alberto, Popa, Daniela, Paoletti, Pierre, Rebola, Nelson
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 03.08.2022; Elsevier; Cell Press
• Subjects: amygdala; cortex; fear; GluN3A; glycine; interneuron; Life Sciences; Neurobiology; Neurons and Cognition; neurotransmission; NMDA; receptors; somatostatin interneurons; tonic activation; cortex; tonic activation; amygdala; neurotransmission; receptors; glycine; somatostatin interneurons; NMDA; interneuron; GluN3A; fear

GluN3A is an atypical glycine-binding subunit of NMDA receptors (NMDARs) whose actions in the brain are mostly unknown. Here, we show that the expression of GluN3A subunits controls the excitability of mouse adult cortical and amygdalar circuits via an unusual signaling mechanism involving the forma...