Parvoviral Host Range and Cell Entry Mechanisms

• Published in: Advances in Virus Research Vol. 70; pp. 183 - 232
• Main Authors: Cotmore, Susan F., Tattersall, Peter
• Format: Book Chapter Journal Article
• Language: English
• Published: United States Elsevier Science & Technology 2007
• Subjects: Amino Acid Sequence; Animals; Canine parvovirus; Cats; Cell Line; Dogs; Humans; Mice; Minute virus of mice; Minute Virus of Mice - chemistry; Minute Virus of Mice - pathogenicity; Minute Virus of Mice - ultrastructure; Models, Molecular; Molecular Sequence Data; Parvoviridae Infections - physiopathology; Parvoviridae Infections - virology; Parvovirus - chemistry; Parvovirus - pathogenicity; Parvovirus - ultrastructure; Parvovirus, Canine - chemistry; Parvovirus, Canine - pathogenicity; Parvovirus, Canine - ultrastructure; Rats; Species Specificity; Virion - chemistry; Virion - ultrastructure; Virology

Parvoviruses elaborate rugged nonenveloped icosahedral capsids of ∼260 Å in diameter that comprise just 60 copies of a common core structural polypeptide. While serving as exceptionally durable shells, capable of protecting the single‐stranded DNA genome from environmental extremes, the capsid also...