Carbofuran metabolism and toxicity in the rat

• Published in: Fundamental and applied toxicology Vol. 4; no. 1; pp. 14 - 21
• Main Authors: Ferguson, Paul W., Dey, Michael S., Jewell, Sarah A., Krieger, Robert I.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Science (USA) 01.01.1984
• Subjects: Acetylcholinesterase - blood; Administration, Oral; Animals; Carbofuran - administration & dosage; Carbofuran - analogs & derivatives; Carbofuran - metabolism; Carbofuran - toxicity; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Erythrocytes - enzymology; Injections, Intravenous; insecticides; Insecticides - metabolism; Male; nematicides; Rats; Rats, Inbred Strains; Time Factors; Tissue Distribution

The influence of carbofuran metabolism on acetylcholinesterase inhibition has been defined after low dose (50 μg/kg, iv and oral) [ carbonyl- 14C]carbofuran exposures to male Sprague-Dawley rats. Red blood cell acetylcholinesterase (RBC AchE) inhibition (83% at 2 min, 37% at 15 min for iv and oral,...