T1 relaxometry of crossing fibres in the human brain

• Published in: NeuroImage (Orlando, Fla.) Vol. 141; pp. 133 - 142
• Main Authors: De Santis, Silvia, Assaf, Yaniv, Jeurissen, Ben, Jones, Derek K, Roebroeck, Alard
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2016; Academic Press
• Subjects: Adult; Brain - anatomy & histology; Brain - metabolism; Diffusion Tensor Imaging - methods; DTI; Female; Humans; Image Enhancement - methods; Image Interpretation, Computer-Assisted - methods; Inversion recovery; Male; Myelin Sheath - metabolism; Myelination; Nerve Fibers, Myelinated - metabolism; Reproducibility of Results; Sensitivity and Specificity; White Matter - diagnostic imaging; White Matter - metabolism; DTI; Myelination; T1; Inversion recovery; T

A comprehensive tract-based characterisation of white matter should include the ability to quantify myelin and axonal attributes irrespective of the complexity of fibre organisation within the voxel. Recently, a new experimental framework that combines inversion recovery and diffusion MRI, called in...