Lithium-induced outcome devaluation in instrumental conditioning: Dose–effect analysis

• Published in: Physiology & behavior Vol. 75; no. 5; pp. 603 - 609
• Main Authors: PAREDES-OLAY, Concepcion, LOPEZ, Matias
• Format: Journal Article
• Language: English
• Published: Cambridge Elsevier Inc 15.04.2002; New York, NY Elsevier
• Subjects: Analysis of Variance; Animal; Animals; Biological and medical sciences; Conditioning; Conditioning, Operant - drug effects; Dose-Response Relationship, Drug; Fundamental and applied biological sciences. Psychology; Instrumental conditioning; Learning. Memory; LiCl dosage; Lithium Chloride - pharmacology; Male; Outcome devaluation; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Psychomotor Performance - drug effects; Rats; Rats, Wistar; Reinforcement (Psychology); Rats; Instrumental conditioning; Outcome devaluation; LiCl dosage; Rat; Rodentia; Lithium; Experimental study; Dose activity relation; Learning; Vertebrata; Mammalia; Acquisition process; Motivation; Animal; Conditioned aversion; Comparative study

Three experiments with rats assessed the effectiveness of various doses of lithium chloride (LiCl) in producing an aversion to the reinforcer on subsequent instrumental performance in extinction. In Experiments 1A and 1B, subjects were injected with LiCl at a dose of 3.0 and 1.5 meq/kg, respectively...