Prevalence of anti-myelin oligodendrocyte glycoprotein antibodies across neuroinflammatory and neurodegenerative diseases

• Published in: Journal of the neurological sciences Vol. 461; p. 123041
• Main Authors: Trivedi, Ritu R., Archambault, Angela S., Pavlak, Clarice, Gastaldi, Matteo, Cantoni, Claudia, Ghezzi, Laura, Cross, Anne H., Miller, Timothy M., Wu, Gregory F.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.06.2024
• Subjects: Adult; Aged; Amyotrophic lateral sclerosis; Amyotrophic Lateral Sclerosis - blood; Amyotrophic Lateral Sclerosis - diagnosis; Amyotrophic Lateral Sclerosis - immunology; Animals; Autoantibodies - blood; Autoantibody; Cell based assay; Female; Humans; Immunoglobulin G - blood; Male; Middle Aged; MOG; MOGAD; Multiple Sclerosis - blood; Multiple Sclerosis - immunology; Myelin-Oligodendrocyte Glycoprotein - immunology; Neurodegeneration; Neurodegenerative Diseases - blood; Neurodegenerative Diseases - diagnosis; Neurodegenerative Diseases - immunology; Neuroinflammatory Diseases - blood; Neuroinflammatory Diseases - immunology; Neurology; MS53; CBA; MOG; Autoantibody; ALS; Amyotrophic lateral sclerosis; CNS; MOGAD; AQP4; ATCC; HAND; OCB; NMO; MFI; EV; Neurodegeneration; ADEM; CSF; Cell based assay; NEALS; HC; Ig; ELISA; Healthy control; Multiple sclerosis; Neuromyelitis optica spectrum disorder; Central nervous system; Immunoglobulin; Cerebrospinal fluid; mean fluorescent intensity; Myelin oligodendrocyte glycoprotein; American Type Culture Collection; Cell-based assay; MOG antibody-associated disease; Northeast ALS Consortium; Oligoclonal bands; Human immunodeficiency virus-1 associated neurocognitive disorder; Aquaporin-4; Acute disseminated encephalomyelitis; enzyme-linked immunosorbent assay; extracellular vesicle

Inflammatory central nervous system (CNS) diseases, such as multiple sclerosis (MS) and myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD), are characterized by humoral immune abnormalities. Anti-MOG antibodies are not specific to MOGAD, with their presence described in MS...