Release of matrix metalloproteinase-9 during balloon angioplasty in patients with stable angina.: A preliminary study

• Published in: International journal of cardiology Vol. 92; no. 2; pp. 177 - 180
• Main Authors: Cedro, Krzysztof, Radomski, Anna, Radomski, Marek W., Ruźyłło, Witold, Herbaczyńska-Cedro, Krystyna
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 01.12.2003; Elsevier Science
• Subjects: Angina Pectoris - metabolism; Angina Pectoris - therapy; Angioplasty, Balloon, Coronary; Balloon angioplasty; Biological and medical sciences; Cardiology. Vascular system; Chromatography, High Pressure Liquid; Coronary heart disease; Diseases of the cardiovascular system; Female; Heart; Humans; Male; Matrix Metalloproteinase 2 - blood; Matrix Metalloproteinase 2 - metabolism; Matrix Metalloproteinase 9 - blood; Matrix Metalloproteinase 9 - metabolism; Matrix metalloproteinases; Medical sciences; Middle Aged; Nitric oxide; Nitric Oxide - metabolism; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Restenosis; Balloon angioplasty; Restenosis; Matrix metalloproteinases; Nitric oxide; Human; Enzyme; Angioplasty; Instrumentation therapy; Metalloendopeptidases; Cardiovascular disease; Instrumental dilatation; Angina pectoris; Coronary heart disease; Gelatinase B; Peptidases; Hydrolases; Release

Background: Vascular wall remodeling is a major factor contributing to restenosis after angioplasty that involves migration and proliferation of vascular smooth muscle cells. The release of matrix-degrading metalloproteinases, including metalloproteinase-2 and metalloproteinase-9, facilitates remode...