Extracellular vesicles as delivery systems at nano-/micro-scale

Schematic illustrations of natural extracellular vesicles versus artificial particles en route to a next-generation drug delivery system. [Display omitted] •Biomechanical properties of extracellular vesicles (EVs) for drug delivery.•Rational designs to improve EVs as next-generation delivery platfor...

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Published inAdvanced drug delivery reviews Vol. 179; p. 113910
Main Authors Fu, Peiwen, Zhang, Jianguo, Li, Haitao, Mak, Michael, Xu, Wenrong, Tao, Zhimin
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.12.2021
Subjects
Drug delivery
Drug Delivery Systems - methods
Drug Stability
Exosomes
Exosomes - metabolism
Extracellular vesicles
Extracellular Vesicles - metabolism
Humans
Nanomaterials
Nanoparticle Drug Delivery System - chemistry
Nanoparticle Drug Delivery System - pharmacokinetics
Particle Size
Extracellular vesicles
Nanomaterials
Drug delivery
Exosomes
Online AccessGet full text

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Abstract Schematic illustrations of natural extracellular vesicles versus artificial particles en route to a next-generation drug delivery system. [Display omitted] •Biomechanical properties of extracellular vesicles (EVs) for drug delivery.•Rational designs to improve EVs as next-generation delivery platforms.•Research advances in loading methods for engineered EVs with their efficiencies.•Progresses and challenges in producing EVs for clinical therapeutics. Extracellular vesicles (EVs) have shown significant promises as nano-/micro-size carriers in drug delivery and bioimaging. With more characteristics of EVs explored through tremendous research efforts, their unmatched physicochemical properties, biological features, and mechanical aspects make them unique vehicles, owning exceptional pharmacokinetics, circulatory metabolism and biodistribution pattern when delivering theranostic cargoes. In this review we firstly analyzed pros and cons of the EVs as a delivery platform. Secondly, compared to engineered nanoparticle delivery systems, such as biocompatible di-block co-polymers, rational design to improve EVs (exosomes in particular) were elaborated. Lastly, different pharmaceutical loading approaches into EVs were compared, reaching a conclusion on how to construct a clinically available and effective nano-/micro-carrier for a satisfactory medical mission.
AbstractList Extracellular vesicles (EVs) have shown significant promises as nano-/micro-size carriers in drug delivery and bioimaging. With more characteristics of EVs explored through tremendous research efforts, their unmatched physicochemical properties, biological features, and mechanical aspects make them unique vehicles, owning exceptional pharmacokinetics, circulatory metabolism and biodistribution pattern when delivering theranostic cargoes. In this review we firstly analyzed pros and cons of the EVs as a delivery platform. Secondly, compared to engineered nanoparticle delivery systems, such as biocompatible di-block co-polymers, rational design to improve EVs (exosomes in particular) were elaborated. Lastly, different pharmaceutical loading approaches into EVs were compared, reaching a conclusion on how to construct a clinically available and effective nano-/micro-carrier for a satisfactory medical mission.Extracellular vesicles (EVs) have shown significant promises as nano-/micro-size carriers in drug delivery and bioimaging. With more characteristics of EVs explored through tremendous research efforts, their unmatched physicochemical properties, biological features, and mechanical aspects make them unique vehicles, owning exceptional pharmacokinetics, circulatory metabolism and biodistribution pattern when delivering theranostic cargoes. In this review we firstly analyzed pros and cons of the EVs as a delivery platform. Secondly, compared to engineered nanoparticle delivery systems, such as biocompatible di-block co-polymers, rational design to improve EVs (exosomes in particular) were elaborated. Lastly, different pharmaceutical loading approaches into EVs were compared, reaching a conclusion on how to construct a clinically available and effective nano-/micro-carrier for a satisfactory medical mission.
Extracellular vesicles (EVs) have shown significant promises as nano-/micro-size carriers in drug delivery and bioimaging. With more characteristics of EVs explored through tremendous research efforts, their unmatched physicochemical properties, biological features, and mechanical aspects make them unique vehicles, owning exceptional pharmacokinetics, circulatory metabolism and biodistribution pattern when delivering theranostic cargoes. In this review we firstly analyzed pros and cons of the EVs as a delivery platform. Secondly, compared to engineered nanoparticle delivery systems, such as biocompatible di-block co-polymers, rational design to improve EVs (exosomes in particular) were elaborated. Lastly, different pharmaceutical loading approaches into EVs were compared, reaching a conclusion on how to construct a clinically available and effective nano-/micro-carrier for a satisfactory medical mission.
Schematic illustrations of natural extracellular vesicles versus artificial particles en route to a next-generation drug delivery system. [Display omitted] •Biomechanical properties of extracellular vesicles (EVs) for drug delivery.•Rational designs to improve EVs as next-generation delivery platforms.•Research advances in loading methods for engineered EVs with their efficiencies.•Progresses and challenges in producing EVs for clinical therapeutics. Extracellular vesicles (EVs) have shown significant promises as nano-/micro-size carriers in drug delivery and bioimaging. With more characteristics of EVs explored through tremendous research efforts, their unmatched physicochemical properties, biological features, and mechanical aspects make them unique vehicles, owning exceptional pharmacokinetics, circulatory metabolism and biodistribution pattern when delivering theranostic cargoes. In this review we firstly analyzed pros and cons of the EVs as a delivery platform. Secondly, compared to engineered nanoparticle delivery systems, such as biocompatible di-block co-polymers, rational design to improve EVs (exosomes in particular) were elaborated. Lastly, different pharmaceutical loading approaches into EVs were compared, reaching a conclusion on how to construct a clinically available and effective nano-/micro-carrier for a satisfactory medical mission.
Extracellular vesicles (EVs) have shown significant promises as nano-/micro-size carriers in drug delivery and bioimaging. With more characteristics of EVs explored through tremendous research efforts, their unmatched physicochemical properties, biological features, and mechanical aspects make them unique vehicles, owning exceptional pharmacokinetics, circulatory metabolism and biodistribution pattern when delivering theranostic cargoes. In this review we firstly analyzed pros and cons of the EVs as a delivery platform. Secondly, compared to engineered nanoparticle delivery systems, such as biocompatible di-block co-polymers, rational design to improve EVs (exosomes in particular) were elaborated. Lastly, different pharmaceutical Loading approaches into EVs were compared, reaching a conclusion on how to construct a clinically available and effective nano-/micro-carrier for a satisfactory medical mission. Schematic illustrations of natural extracellular vesicles versus artificial particles en route to a next-generation drug delivery system.
ArticleNumber 113910
Author Tao, Zhimin
Fu, Peiwen
Zhang, Jianguo
Li, Haitao
Mak, Michael
Xu, Wenrong
AuthorAffiliation 2 Zhenjiang Municipal Key Laboratory of High Technology for Basic and Translational Research on Exosomes, Zhenjiang 212013, China
5 Department of Biomedical Engineering, School of Engineering and Applied Science, Yale University, New Haven 06520, USA
1 Jiangsu Province Key laboratory of Medical Science and laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang 212013, China
3 Department of Critical Care Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China
4 Institute for Energy Research, School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China
AuthorAffiliation_xml – name: 5 Department of Biomedical Engineering, School of Engineering and Applied Science, Yale University, New Haven 06520, USA
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Keywords Extracellular vesicles
Nanomaterials
Drug delivery
Exosomes
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Snippet Schematic illustrations of natural extracellular vesicles versus artificial particles en route to a next-generation drug delivery system. [Display omitted]...
Extracellular vesicles (EVs) have shown significant promises as nano-/micro-size carriers in drug delivery and bioimaging. With more characteristics of EVs...
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StartPage 113910
SubjectTerms Drug delivery
Drug Delivery Systems - methods
Drug Stability
Exosomes
Exosomes - metabolism
Extracellular vesicles
Extracellular Vesicles - metabolism
Humans
Nanomaterials
Nanoparticle Drug Delivery System - chemistry
Nanoparticle Drug Delivery System - pharmacokinetics
Particle Size
Title Extracellular vesicles as delivery systems at nano-/micro-scale
URI https://dx.doi.org/10.1016/j.addr.2021.113910
https://www.ncbi.nlm.nih.gov/pubmed/34358539
https://www.proquest.com/docview/2559430495
https://pubmed.ncbi.nlm.nih.gov/PMC8986465
Volume 179
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