Brain processing of visual sexual stimuli in men with hypoactive sexual desire disorder
Although hypoactive sexual desire disorder (HSDD) is a common condition and has long been hypothesized to result from malfunctions of the cerebral control mechanisms that adjust the level of sexual motivation, very little is known about the pathophysiology of this disorder. The primary objective was...
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| Published in | Psychiatry research Vol. 124; no. 2; pp. 67 - 86 |
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| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Shannon
Elsevier Ireland Ltd
30.10.2003
Elsevier |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0925-4927 0165-1781 1872-7506 |
| DOI | 10.1016/S0925-4927(03)00068-4 |
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| Abstract | Although hypoactive sexual desire disorder (HSDD) is a common condition and has long been hypothesized to result from malfunctions of the cerebral control mechanisms that adjust the level of sexual motivation, very little is known about the pathophysiology of this disorder. The primary objective was to identify in patients with HSDD brain regions where functional perturbations disrupt the regulation of sexual motivation. We used positron emission tomography to compare seven male patients with HSDD with eight healthy men on their regional cerebral blood flow responses to visual sexual stimuli (VSS) of graded intensity. Statistical Parametric Mapping was used to locate brain regions that demonstrated a differential activation (or deactivation) across the groups. Whereas in control subjects the medial orbitofrontal cortex showed a deactivation in response to VSS, in HSDD patients there was an abnormally maintained activity of this region, which has been implicated in the inhibitory control of motivated behavior. By contrast, the reverse pattern—activation in control subjects, deactivation or unchanged activity in patients—was found in the secondary somatosensory cortex and inferior parietal lobules, regions mediating emotional and motor imagery processes, as well as in those areas of the anterior cingulate gyrus and of the frontal lobes that are involved in premotor processes. |
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| AbstractList | Although hypoactive sexual desire disorder (HSDD) is a common condition and has long been hypothesized to result from malfunctions of the cerebral control mechanisms that adjust the level of sexual motivation, very little is known about the pathophysiology of this disorder. The primary objective was to identify in patients with HSDD brain regions where functional perturbations disrupt the regulation of sexual motivation. We used positron emission tomography to compare seven male patients with HSDD with eight healthy men on their regional cerebral blood flow responses to visual sexual stimuli (VSS) of graded intensity. Statistical Parametric Mapping was used to locate brain regions that demonstrated a differential activation (or deactivation) across the groups. Whereas in control subjects the medial orbitofrontal cortex showed a deactivation in response to VSS, in HSDD patients there was an abnormally maintained activity of this region, which has been implicated in the inhibitory control of motivated behavior. By contrast, the reverse pattern-activation in control subjects, deactivation or unchanged activity in patients-was found in the secondary somatosensory cortex and inferior parietal lobules, regions mediating emotional and motor imagery processes, as well as in those areas of the anterior cingulate gyrus and of the frontal lobes that are involved in premotor processes.Although hypoactive sexual desire disorder (HSDD) is a common condition and has long been hypothesized to result from malfunctions of the cerebral control mechanisms that adjust the level of sexual motivation, very little is known about the pathophysiology of this disorder. The primary objective was to identify in patients with HSDD brain regions where functional perturbations disrupt the regulation of sexual motivation. We used positron emission tomography to compare seven male patients with HSDD with eight healthy men on their regional cerebral blood flow responses to visual sexual stimuli (VSS) of graded intensity. Statistical Parametric Mapping was used to locate brain regions that demonstrated a differential activation (or deactivation) across the groups. Whereas in control subjects the medial orbitofrontal cortex showed a deactivation in response to VSS, in HSDD patients there was an abnormally maintained activity of this region, which has been implicated in the inhibitory control of motivated behavior. By contrast, the reverse pattern-activation in control subjects, deactivation or unchanged activity in patients-was found in the secondary somatosensory cortex and inferior parietal lobules, regions mediating emotional and motor imagery processes, as well as in those areas of the anterior cingulate gyrus and of the frontal lobes that are involved in premotor processes. Although hypoactive sexual desire disorder (HSDD) is a common condition and has long been hypothesized to result from malfunctions of the cerebral control mechanisms that adjust the level of sexual motivation, very little is known about the pathophysiology of this disorder. The primary objective was to identify in patients with HSDD brain regions where functional perturbations disrupt the regulation of sexual motivation. We used positron emission tomography to compare seven male patients with HSDD with eight healthy men on their regional cerebral blood flow responses to visual sexual stimuli (VSS) of graded intensity. Statistical Parametric Mapping was used to locate brain regions that demonstrated a differential activation (or deactivation) across the groups. Whereas in control subjects the medial orbitofrontal cortex showed a deactivation in response to VSS, in HSDD patients there was an abnormally maintained activity of this region, which has been implicated in the inhibitory control of motivated behavior. By contrast, the reverse pattern-activation in control subjects, deactivation or unchanged activity in patients-was found in the secondary somatosensory cortex and inferior parietal lobules, regions mediating emotional and motor imagery processes, as well as in those areas of the anterior cingulate gyrus and of the frontal lobes that are involved in premotor processes. |
| Author | Dechaud, Henri Pugeat, Michel Costes, Nicolas Bars, Didier Le Redouté, Jérôme Lavenne, Frank Forest, Maguelone G. Stoléru, Serge Cinotti, Luc Pujol, Jean-François |
| Author_xml | – sequence: 1 givenname: Serge surname: Stoléru fullname: Stoléru, Serge email: serge.stoleru@snv.jussieu.fr organization: Inserm, Unité 483, Université Pierre et Marie Curie, Boite 23, 9 quai Saint-Bernard, 75252 Paris Cedex 05, France – sequence: 2 givenname: Jérôme surname: Redouté fullname: Redouté, Jérôme organization: Inserm, Unité 483, Université Pierre et Marie Curie, Boite 23, 9 quai Saint-Bernard, 75252 Paris Cedex 05, France – sequence: 3 givenname: Nicolas surname: Costes fullname: Costes, Nicolas organization: Centre d'Etudes et de Recherches Médicales par Emission de Positons, Lyon, France – sequence: 4 givenname: Frank surname: Lavenne fullname: Lavenne, Frank organization: Centre d'Etudes et de Recherches Médicales par Emission de Positons, Lyon, France – sequence: 5 givenname: Didier Le surname: Bars fullname: Bars, Didier Le organization: Centre d'Etudes et de Recherches Médicales par Emission de Positons, Lyon, France – sequence: 6 givenname: Henri surname: Dechaud fullname: Dechaud, Henri organization: Service de Radiopharmacie et de Radioanalyse, Hôpitaux de Lyon, Lyon, France – sequence: 7 givenname: Maguelone G. surname: Forest fullname: Forest, Maguelone G. organization: Unité 329, Inserm, Lyon, France – sequence: 8 givenname: Michel surname: Pugeat fullname: Pugeat, Michel organization: Fédération d'Endocrinologie, Hôpital de l'Antiquaille, Lyon, France – sequence: 9 givenname: Luc surname: Cinotti fullname: Cinotti, Luc organization: Centre d'Etudes et de Recherches Médicales par Emission de Positons, Lyon, France – sequence: 10 givenname: Jean-François surname: Pujol fullname: Pujol, Jean-François organization: Centre d'Etudes et de Recherches Médicales par Emission de Positons, Lyon, France |
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| Keywords | Parietal lobe Prefrontal cortex Inhibition Motivation Cingulate gyrus Sexuality Human Orbitofrontal cortex Desire Central nervous system Male Encephalon Somatosensory cortex Visual stimulus Sexual behavior disorder Cingulate cortex |
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| Title | Brain processing of visual sexual stimuli in men with hypoactive sexual desire disorder |
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