Somal size of prefrontal cortical pyramidal neurons in schizophrenia: differential effects across neuronal subpopulations

• Published in: Biological psychiatry (1969) Vol. 54; no. 2; pp. 111 - 120
• Main Authors: Pierri, Joseph N, Volk, Christine L.E, Auh, Sungyoung, Sampson, Allan, Lewis, David A
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 15.07.2003; Elsevier Science
• Subjects: Adult; Adult and adolescent clinical studies; Aged; Autopsy; Biological and medical sciences; Case-Control Studies; Cell Count; Female; Humans; Immunohistochemistry; Investigative techniques, diagnostic techniques (general aspects); Male; Medical sciences; Middle Aged; Nervous system; neurofilament protein; Neurofilament Proteins - analysis; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; postmortem; prefrontal cortex; Prefrontal Cortex - pathology; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Pyramidal Cells - pathology; pyramidal neurons; Schizophrenia; Schizophrenia - pathology; somal size; Schizophrenia; pyramidal neurons; neurofilament protein; postmortem; prefrontal cortex; somal size; Human; Pathophysiology; Postmortem; Exploration; Prefrontal cortex; Cell subpopulation; Psychosis; Neurofilament; Immunoreactive form; Pyramidal neuron; Cadaver; Comparative study

Cognitive dysfunction in schizophrenia may be related to morphologic abnormalities of pyramidal neurons in the dorsal prefrontal cortex (dPFC) and the largest pyramidal neurons in deep layer 3 may be most affected. Immunoreactivity (IR) for the nonphosphorylated epitopes of neurofilament protein (NN...