Inflammatory pathways and cholangiocarcinoma risk mechanisms and prevention

• Published in: Advances in cancer research Vol. 156; pp. 39 - 73
• Main Authors: Cadamuro, Massimiliano, Strazzabosco, Mario
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 2022
• Subjects: Bile Duct Neoplasms - prevention & control; Bile Ducts, Intrahepatic - pathology; Cholangiocarcinogenesis; Cholangiocarcinoma - etiology; Cholangiocarcinoma - prevention & control; Cholangitis, Sclerosing - complications; Cholangitis, Sclerosing - pathology; Congenital hepatic fibrosis; Fluke infestations; Humans; Intrahepatic cholangiocarcinoma; Primary sclerosing cholangitis; Risk Factors; Therapeutic targets; Primary sclerosing cholangitis; Cholangiocarcinogenesis; Congenital hepatic fibrosis; Fluke infestations; Intrahepatic cholangiocarcinoma; Therapeutic targets
• ISSN: 0065-230X; 2162-5557; 2162-5557
• DOI: 10.1016/bs.acr.2022.02.001

Cholangiocarcinoma (CCA), a neoplasm burdened by a poor prognosis and currently lacking adequate therapeutic treatments, can originate at different levels of the biliary tree, in the intrahepatic, hilar, or extrahepatic area. The main risk factors for the development of CCA are the presence of chron...