Early events in murine erythroleukemia cells induced to differentiate: Accumulation and gene expression of the transformation-associated cellular protein p53

• Published in: Journal of molecular biology Vol. 200; no. 1; pp. 55 - 64
• Main Authors: Khochbin, Saadi, Principaud, Etienne, Chabanas, Agnès, Lawrence, Jean-Jacques
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 05.03.1988; Elsevier
• Subjects: Acetamides - pharmacology; Animals; Biological and medical sciences; Cell Differentiation - drug effects; Cell Line; Cell physiology; Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes; Cycloheximide - pharmacology; Dactinomycin - pharmacology; Flow Cytometry; Fundamental and applied biological sciences. Psychology; Half-Life; Kinetics; Leukemia, Erythroblastic, Acute - genetics; Leukemia, Erythroblastic, Acute - metabolism; Mice; Molecular and cellular biology; Neoplasm Proteins - metabolism; Phosphoproteins - metabolism; RNA, Messenger - metabolism; Tumor Suppressor Protein p53; PBS; MEM; DMSO; HMBA; RNP; kb; scRNA; FCS; MELC; Erythroleukemia; Cell culture; Induction; Rodentia; Cell differentiation; Gene expression; Cell transformation; Accumulation; Proteins; Vertebrata; Mammalia; Mouse; Animal

Oncogenes may play a crucial role in the genetic program of cellular differentiation; even. probably, at a very early stage in this program, which can be described as pre-commitment. We have investigated the variation in, and the control level of, the accumulation of the transformation-associated ce...