Taurine antagonizes the increase in intracellular calcium concentration induced by α-adrenergic stimulation in freshly isolated guinea-pig cardiomyocytes

• Published in: Journal of molecular and cellular cardiology Vol. 24; no. 11; pp. 1253 - 1265
• Main Authors: Failli, Paola, Fazzini, Alessandro, Franconi, Flavia, Stendardi, Isabella, Giotti, Alberto
• Format: Journal Article
• Language: English
• Published: Kent Elsevier Ltd 01.11.1992; Elsevier
• Subjects: Adult cardiomyocytes; Animals; Biological and medical sciences; Calcium - metabolism; Fundamental and applied biological sciences. Psychology; Fura-2; Guinea Pigs; Heart; Heart - drug effects; In Vitro Techniques; Intracellular calcium concentration; Intracellular Fluid - drug effects; Intracellular Fluid - metabolism; Male; Myocardium - cytology; Myocardium - metabolism; Phenylephrine - pharmacology; Taurine; Taurine - pharmacology; Vertebrates: cardiovascular system; α-adrenoceptor stimulation; β-alanine; Taurine; β-alanine; Adult cardiomyocytes; Intracellular calcium concentration; α-adrenoceptor stimulation; Heart; Calcium; Rodentia; Stimulation; Myocyte; Vertebrata; Mammalia; Guinea pig; α-Adrenergic receptor; Concentration effect; Circulatory system; Antagonist; Intracellular

The effect of taurine on phenylephrine α-adrenergic action was studied in freshly-isolated guinea-pig ventricular myocytes. Intracellular calcium concentration was measured at nearly physiological extracellular CaCl 2 in both cell suspension using quin-2 (mean intracellular calcium concentration 154...