Chronic cat allergen exposure induces a TH2 cell–dependent IgG4 response related to low sensitization

• Published in: Journal of allergy and clinical immunology Vol. 136; no. 6; pp. 1627 - 1635.e13
• Main Authors: Renand, Amedee, Archila, Luis D., McGinty, John, Wambre, Erik, Robinson, David, Hales, Belinda J., Thomas, Wayne R., Kwok, William W.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2015
• Subjects: Adult; Aged; allergen exposure; allergen tolerance; Allergens - immunology; Animals; asthma; B-Lymphocytes - immunology; Cat allergy; Cats - immunology; CD154; class II tetramer; Fel d 1; Fel d 4; Humans; Hypersensitivity - blood; Hypersensitivity - immunology; IgG4; Immunoglobulin E - blood; Immunoglobulin G - blood; Immunoglobulin G - immunology; Middle Aged; Skin Tests; T-Lymphocytes - immunology; TH2 cells; CD154; Cat allergy; IgG4; Fel d 4; asthma; class II tetramer; Fel d 1; allergen tolerance; allergen exposure; TH2 cells; APC; PE; TFH; CRTH2; sTH2; T(H)2 cells; IgG

In human subjects, allergen tolerance has been observed after high-dose allergen exposure or after completed allergen immunotherapy, which is related to the accumulation of anti-inflammatory IgG4. However, the specific T-cell response that leads to IgG4 induction during chronic allergen exposure rem...