Pathophysiological significance of in vivo ESR signal decay in brain damage caused by X-irradiation: Radiation effect on nitroxyl decay of a lipophilic spin probe in the head region

• Published in: Biochimica et biophysica acta Vol. 1525; no. 1; pp. 167 - 172
• Main Authors: Miura, Yuri, Anzai, Kazunori, Ueda, Jun-Ichi, Ozawa, Toshihiko
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 16.02.2001
• Subjects: 3-Methoxycarbonyl-2,2,5,5-tetramethylpyrrolidine-1-yloxy; Animals; Brain; Brain Injuries - physiopathology; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Female; In Vitro Techniques; In vivo electron spin resonance; Mice; Nitrogen Oxides - chemistry; Nitrogen Oxides - radiation effects; Nitroxyl radical; Pyrrolidines - chemistry; Pyrrolidines - radiation effects; Radiation; Radiation Injuries, Experimental - physiopathology; Spin Labels; Brain; In vivo electron spin resonance; Nitroxyl radical; 3-Methoxycarbonyl-2,2,5,5-tetramethylpyrrolidine-1-yloxy; Radiation

X-irradiation of mice decreased the decay rate of the in vivo ESR signal in the head region to 75% of the control when 3-methoxycarbonyl-2,2,5,5-tetramethylpyrrolidine-1-yloxy (MCPROXYL), a lipophilic and blood–brain barrier-permeable spin probe, was used. We attempted to identify the specific facto...