Elderly Aggressive-Histology Non-Hodgkin's Lymphoma: First-Line VNCOP-B Regimen Experience on 350 Patients

• Published in: Blood Vol. 94; no. 1; pp. 33 - 38
• Main Authors: Zinzani, Pier Luigi, Storti, Sergio, Zaccaria, Alfonso, Moretti, Luciano, Magagnoli, Massimo, Pavone, Enzo, Gentilini, Patrizia, Guardigni, Luciano, Gobbi, Marco, Fattori, Pier Paolo, Falini, Brunangelo, Lauta, Vito Michele, Bendandi, Maurizio, Gherlinzoni, Filippo, De Renzo, Amalia, Zaja, Francesco, Mazza, Patrizio, Volpe, Ettore, Bocchia, Monica, Aitini, Enrico, Tabanelli, Maurizio, Leone, Giuseppe, Tura, Sante
• Format: Journal Article
• Language: English
• Published: Washington, DC Elsevier Inc 01.07.1999; The Americain Society of Hematology
• Subjects: Aged; Aged, 80 and over; Antineoplastic agents; Antineoplastic Combined Chemotherapy Protocols - administration & dosage; Biological and medical sciences; Bleomycin - administration & dosage; Chemotherapy; Cohort Studies; Cyclophosphamide - administration & dosage; Disease-Free Survival; Etoposide - administration & dosage; Female; Granulocyte Colony-Stimulating Factor - administration & dosage; Humans; Lymphoma, Non-Hodgkin - drug therapy; Lymphoma, Non-Hodgkin - pathology; Lymphoma, Non-Hodgkin - physiopathology; Male; Medical sciences; Mitoxantrone - administration & dosage; Pharmacology. Drug treatments; Prednisone - administration & dosage; Remission Induction; Survival Analysis; Vincristine - administration & dosage; Antineoplastic agent; Prognosis; Glucocorticoid; Alkaloid; Isomerases; Bleomycin; Lymphoproliferative syndrome; Adult; Mitoxantrone; Antimitotic; Human; Corticosteroid; DNA topoisomerase (ATP-hydrolysing); Drug combination; Anthraquinone derivatives; Enzyme; Etoposide; Enzyme inhibitor; Malignant hemopathy; Prednisone; Non Hodgkin lymphoma; Vincristine; Podophyllotoxine derivatives; Alkylating agent; Antibiotic; Chemotherapy; Cyclophosphamide; Oxazaphosphinane derivatives; Treatment; Antimetabolic; Follow up study; Nitrogen mustard; Therapeutic protocol; Elderly

Age is a risk factor and a prognostic parameter in elderly aggressive-histology non-Hodgkin's lymphoma (NHL) patients. Several adapted chemotherapeutic regimens have recently been designed and tested on elderly patients. Several of these trials have shown that older aggressive-histology NHL pat...