How Homologous Recombination Is Initiated: Unexpected Evidence for Single-Strand Nicks from V(D)J Site-Specific Recombination

Views of how homologous recombination is initiated have changed over the past several decades: in the 1960s and 1970s, single-strand DNA lesions (nicks) were the leading contenders, but in the last decade, double-strand DNA breaks (DSBs) have reigned. In this issue of Cell, Lee et al. (2004) present...

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Bibliographic Details
Published inCell Vol. 117; no. 2; pp. 146 - 148
Main Author Smith, Gerald R
Format Book Review Journal Article
LanguageEnglish
Published United States Elsevier Inc 16.04.2004
Subjects
Animals
DNA Damage - genetics
DNA, Single-Stranded - genetics
Gene Rearrangement - genetics
Humans
Mutagenesis, Site-Directed - genetics
Recombination, Genetic - genetics
Sequence Homology, Nucleic Acid
Translocation, Genetic - genetics
VDJ Recombinases - metabolism
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Summary:Views of how homologous recombination is initiated have changed over the past several decades: in the 1960s and 1970s, single-strand DNA lesions (nicks) were the leading contenders, but in the last decade, double-strand DNA breaks (DSBs) have reigned. In this issue of Cell, Lee et al. (2004) present evidence that nicks can stimulate homologous recombination and, in uncontrolled situations, may lead to translocations and other potentially dangerous genome rearrangements.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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ISSN:0092-8674
1097-4172
DOI:10.1016/S0092-8674(04)00338-1