Proximal signaling events in FcεRI-mediated mast cell activation

• Published in: Journal of allergy and clinical immunology Vol. 119; no. 3; pp. 544 - 552
• Main Authors: Kambayashi, Taku, MD, PhD, Koretzky, Gary A., MD, PhD
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier 01.03.2007
• Subjects: Adaptor Proteins, Signal Transducing - metabolism; Allergy and Immunology; Biological and medical sciences; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Humans; Hypersensitivity - drug therapy; Hypersensitivity - immunology; Immunopathology; Mast Cells - drug effects; Mast Cells - immunology; Medical sciences; Protein Kinase C - metabolism; Protein Structure, Tertiary; Receptors, IgE - chemistry; Receptors, IgE - genetics; Receptors, IgE - metabolism; Signal Transduction - drug effects; Src homology 2 domain-containing phosphatase 1; Linker for activation of T cell; Protein kinase C; IgE; JNK; PLC; PTK; Diacylglycerol; GBF; SHP-1; PI3K; NTAL; Protein tyrosine kinase; SHIP; PSA; Src homology 2 domain-containing leukocyte-specific phosphoprotein of 76 kd; Phosphatidylinositol-3 kinase; SLP-76; Syk; Non–T-cell activation linker; Extracellular signal-regulated kinase; allergy; PKC; Grb-associated binder 2; DAG; Gab2; s-Jun N-terminal kinase; Bruton's tyrosine kinase; Mitogen-activated protein; Gads-binding fragment; Phospholipase C; Spleen tyrosine kinase; adapter molecules; ITAM; cell signaling; Passive systemic anaphylaxis; Btk; Mast cell; FcεRI; Immunoreceptor tyrosine-based activation motif; Src homology 2-containing inositol phosphatase; MAP; LAT; ERK; Proximal; Immunopathology; Allergy; Enzyme; Transferases; FcεRI receptor; Immunoglobulin receptor; FCεRI; Signal transduction; Immunology; Protein-tyrosine kinase

Mast cells are central mediators of allergic diseases. Their involvement in allergic reactions is largely dependent on activation through the specific receptor for IgE (FcεRI). Cross-linking of FcεRI on mast cells initiates a cascade of signaling events that eventually results in degranulation, cyto...