ADP-induced platelet aggregation and inhibition of adenylyl cyclase activity stimulated by prostaglandins : Signal transduction mechanisms

• Published in: Biochemical pharmacology Vol. 57; no. 8; pp. 851 - 859
• Main Author: Puri, Rajinder N.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 15.04.1999; Elsevier Science
• Subjects: Adenosine Diphosphate - physiology; Adenylyl Cyclase Inhibitors; adenylyl cyclase, activation and inhibition of; Adenylyl Cyclases - metabolism; ADP; Biological and medical sciences; Cell physiology; Enzyme Activation; Fundamental and applied biological sciences. Psychology; G-proteins; GTP-Binding Proteins - metabolism; Humans; Molecular and cellular biology; phospholipases; Phospholipases - metabolism; Platelet Activation; platelet aggregation; Platelet Aggregation - physiology; Prostaglandins - physiology; Signal transduction; Signal Transduction - physiology; phospholipases; adenylyl cyclase, activation and inhibition of; signal transduction; ADP; G-proteins; platelet aggregation; Prostaglandin; Enzyme; Phosphorus-oxygen lyases; Esterases; Lyases; Activation; Phosphoric diester hydrolases; Review; Phospholipase A; Carboxylic ester hydrolases; Phospholipase C; Aggregation; Adenylate cyclase; Signal transduction; Platelet; Hydrolases; Inhibition; G protein; Biological receptor

ADP is the oldest and one of the most important agonists of platelet activation. ADP induces platelet shape change, exposure of fibrinogen binding sites, aggregation, and influx and intracellular mobilization of Ca 2+. ADP-induced platelet aggregation is important for maintaining normal hemostasis,...